BiasDB is a manually curated database containing all published biased GPCR ligands. BiasDB currently contains 727 bias cases of signaling bias representing 547 individual ligands for 61 receptors. We provide information about the chemical structure, target receptor, type of bias, assay categories used for bias determination, reference ligand and literature source. BiasDB is a resource for medicinal chemists, pharmacologists and researchers interested in biased GPCR signaling.
G protein-coupled receptors (GPCRs) represent important drug targets with complex pharmacological characteristics.
Biased signaling represents one important dimension of this complexity describing ligand-dependent shifts of naturally
imprinted signaling profiles. Since biased GPCR modulators provide potential therapeutic benefits including higher efficiencies and reduced
adverse effects, the identification of such ligands as drug candidates is highly